Final Exam
- Final Examination – Research on newly approved drug in 2023
- Each student will be assigned a drug approved in 2023
- Two parts – Written and Oral
- Written research report – May 12 – for all the students
- 2000 words minimum. No limit on maximum words
- Includes figures, graphs, data and tables to support your writing (from research papers)
- Include 3 references and more if you like (at the end of paper)
- One of the references could be patent. If you include patent, then discuss it.
- Oral Presentation of you work in the classroom – Week of 15, 16 and week 17
- 10 to 12 minutes presentation
- Walk us through your report about the drug
- Slide deck is due 24 hrs before your presentation
- Written research report – May 12 – for all the students
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- Drug information
- Package insert
- Web search: “PDF package insert Plavix”
- Package insert is posted on LinkedIn
Identify three research papers, download and
submit PDF files online
- Definition, Classification and Diagnosis of Diabetes Mellitus. Petersmann A, Müller-Wieland D, Müller UA, Landgraf R, Nauck M, Freckmann G, Heinemann L, Schleicher E., Exp Clin Endocrinol Diabetes. 2019, 127 (S 01) p.S1-S7
- New Possibilities in the Therapeutic Approach to Alzheimer’s Disease. Doroszkiewicz J, Mroczko B. Int J Mol Sci. 2022, 23 (16), p8902. doi: 10.3390/ijms23168902.
- Ishino, T.; Palanki, M. S. S.; Violand, B.; Das, T.; Hodge, T.; Levin, N.; Parsons, E. Anti-diabetic compounds comprising fibroblast growth factor FGF21 covalently attached to combining site of antibody with prepared linker. WO 2012059873.
Final Exam – research paper and class room
presentation – What to present
- Introduction to diseases
- Describe the diseases (symptoms and biology behind it)
- Biological mechanism of diseases
- Biological target for the drug
- Patent information (google search, Espacenet.com )
- Approach – small molecules vs. biologics
- How was the drug was made (chemical vs. biological), structure, synthesis,
- Scientific summary – clinical pharmacology
- How the drug was absorbed, distributed, metabolized, eliminated (Pharmacokinetics)
- What are the effects of drug on the body and on the diseases (Pharmacodynamics
- Clinical studies (use package insert as guide)
- Regulatory pathways
- Recommended dosages, side effects, drug interactions
- Information of use of drug in specific population, pediatric use, Geriatric use, ethnic use, pregnancy use, lactating mothers